Virus entry paradigms
نویسندگان
چکیده
منابع مشابه
Epstein-Barr virus entry.
One of the many conundrums of herpesvirology is why a herpesvirus is so profligate in its use of four or more envelope glycoproteins for entry into a cell when other viruses can manage very well with only one or two. Profligacy does, however, have its advantages. Epstein-Barr virus (EBV), originally recognized for its ability to infect and transform lymphocytes, is now clearly understood to inf...
متن کاملHepatitis C virus entry.
Hepatitis C virus (HCV) is a hepatotropic virus and a major cause of chronic hepatitis and liver disease worldwide. Initial interactions between HCV virions and hepatocytes are required for productive viral infection and initiation of the viral life cycle. Furthermore, HCV entry contributes to the tissue tropism and species specificity of this virus. The elucidation of these interactions is cri...
متن کاملVirus Entry by Endocytosis
Although viruses are simple in structure and composition, their interactions with host cells are complex. Merely to gain entry, animal viruses make use of a repertoire of cellular processes that involve hundreds of cellular proteins. Although some viruses have the capacity to penetrate into the cytosol directly through the plasma membrane, most depend on endocytic uptake, vesicular transport th...
متن کاملVirus Entry: Open Sesame
Detailed information about the replication cycle of viruses and their interactions with host organisms is required to develop strategies to stop them. Cell biology studies, live-cell imaging, and systems biology have started to illuminate the multiple and subtly different pathways that animal viruses use to enter host cells. These insights are revolutionizing our understanding of endocytosis an...
متن کاملNew Anti-Influenza Agents: Targeting the Virus Entry and Genome Transcription
Introduction: The emergence and spread of the pandemic H1N1 influenza virus in 2009 indicates a limitation in the strategy to control the infection, despite a long-established vaccination programme and approved antivirals. Production the proper vaccine against influenza is difficult due to the genetic recombination of virus in the event of pandemic and co-circulation of drug-resistance variants...
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ژورنال
عنوان ژورنال: Amino Acids
سال: 2009
ISSN: 0939-4451,1438-2199
DOI: 10.1007/s00726-009-0363-3